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无证据支持无症状群体常规使用阿司匹林——来自AAA研究的结果
根据阿司匹林(拜耳公司)在无症状性动脉粥样硬化患者中的应用研究(Aspirin for Asymptomatic Atherosclerosis study,AAA)的结果,并不支持日常常规使用阿司匹林用于无症状人群中血管事件的初级预防.该研究是首项安慰剂对照随机试验,旨在确定阿司匹林在通过踝臂指数(ABI)低反应出来的无症状性动脉粥样硬化人群中作用的研究.研究结果发现使用阿司匹林和使用安慰剂的研究对象之间在初级结果事件的发生上并没有统计学方面的显著差异.
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阿司匹林用于心血管疾病一级预防的新进展
减少心血管病危害的关键在预防.二级预防针对已经确诊的心血管病患者,旨在减少再发心血管病事件(心肌梗死、脑卒中或心血管病死亡);一级预防的对象是非心血管病患者,目的是避免或推迟首次心血管病事件.阿司匹林是二级预防的主要措施之一,但在心血管病一级预防中的价值仍有争论[1].
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Mechanisms of inhibition by aspirin of endometrial carcinoma cell proliferation,migration and invasion
Objective:To investigate the effects and mechanisms of aspirin on the proliferation,migration and invasion of endometrial carcinoma HEC-1A cell lines.Methods:HEC-1A cells were cultured to the exponential phase and treated with different concentrations of aspirin (0.625 mmol/ L,1.25 mmol/L,2.5 mmol/L,5 mmol/L and 10 mmol/L) for 24 to 120 hours.Cell proliferation was assessed by methyl thiazolyl tetrazolium (MTT) assay.The migration and invasion of HEC-1A cells were detected by transwell assay.The protein expressions of vascular endothelial growth factor (VEGF) and ascular endothelial growth factor receptor 2 (VEGFR-2) in HEC-1A cells were determined by western blotting.Results:MTT results showed that aspirin inhibited the growth and proliferation of endometrial cancer cells in concentration and time-dependent manner.Aspirin had a significant inhibitory effect on the migration and invasion of HEC-1A cells (P<0.05).In addition,aspirin obviously suppressed concentration-dependently the expression levels of VEGF and VEGFR-2 (P < 0.05).Conclusion:Aspirin could inhibit the proliferation,migration and invasion of endometrial cancer cells.The anti-tumor mechanism of aspirin might be related to the inhibition of tumor angiogenesis via blocking the VEGF/VEGFR-2 signaling pathway.
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Effect of aspirin on glucose-D transport in intestine of rat
Objective: The present study was designed to evaluate the effect a commonly prescribed Non Steroidal Anti In-flammatory Drug (NSAID) i.e. aspirin on brush border membrane in terms of changes in the intestinal transport level of glucose which is monosaccharide with absolute requirement in the body and hence its absorption is directly proportional on the morphology of the intestinal mucosa. Method: Albino rats (Rattus Norvegicus) were divided into two different groups, Group Ⅰ (Control), Group Ⅱ ( aspirin-treated, 50 mg aspirin/kg of body weight). The treatment was continued for 28 days. On the 29th day after o-, vernight fasting, intestine was removed from animals of both groups. Changes in transport of glucose-D in intestine were studied. Result: The results indicated a significant decrease in the transport of glucose-D in aspirin treated group as compared to the con-trol group. Conclusion: Cautious use of NSAID is recommended in commonly observed symptom such as headache and to those patients who are given as a prophylaxis for thrombosis.
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防治心脑血管病的ABCDE
1 A(Aspirin)-使用阿司匹林世界卫生组织(WHO)数据显示,心脑血管疾病是全球的首要致死原因,约占慢性疾病致死人数的30%,与西方发达国家不同,我国脑卒中的威胁远胜于心脏病,发病率不但持续升高,且致残率和死亡率更高.
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The main role of antiplatelet therapy in the management of patients with acute ischaemic stroke is to prevent a recurrent stroke or other serious vascular event, such as myocardial infarction.