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Adrenocortical hormone (ACH) has antiinflammatory and antiallergic actions, changes stress state and controls the attack of some severe and obstinate diseases. The treatment of chronic diseases with ACH often leads to its dependence; especially oral administration of ACH for a long time is liable to inhibit the function of hypothalamus-pituitary-adrenocortical-thymic axis (HPAT), and results in the hypo-reservation of adrenal cortex. Hence, sudden ACH withdrawal or decrease often causes the disease recurrence, even adrenocortical crisis. Academician Shen Ziyin has a wealth of clinical experience in both the withdrawal and reduction of ACH and the keeping of therapeutical effectiveness to form his unique remedy in the application of drugs. Shen's rich experience is described as follows.
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生态免疫营养与应激状态下的感染防治
对胃肠道尚有功能的手术或创伤后患者给予肠内营养,其效果优于肠外营养,这已成共识.早期肠内营养可以刺激和改善内脏及肠黏膜血液循环,防止或减轻胃肠道缺血和肠道通透性紊乱,减少应激性溃疡的发生.然而,市售的肠内营养制剂配方主要为供小肠消化、吸收的营养物质,忽略了结肠的生理功能.人体10%的能量来自结肠,结肠黏膜细胞的营养物质主要为肠腔生理性细菌酵解纤维后的产物.在疾病应激状态下,尤其是应用抗生素和其他药品后,肠道原有的生理性细菌大大减少,相反致病菌增多且毒性增强,内源性感染就在所难免.1996年Bengmark等[1]首先提出生态免疫营养的概念,即在肠内营养支持中添加黏膜重建要素成分--新的表面活性物质(如极性脂类)、纤维、精氨酸和能黏附黏膜的乳酸菌(lactic acid bacteria,LAB).
