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Adrenocortical hormone (ACH) has antiinflammatory and antiallergic actions, changes stress state and controls the attack of some severe and obstinate diseases. The treatment of chronic diseases with ACH often leads to its dependence; especially oral administration of ACH for a long time is liable to inhibit the function of hypothalamus-pituitary-adrenocortical-thymic axis (HPAT), and results in the hypo-reservation of adrenal cortex. Hence, sudden ACH withdrawal or decrease often causes the disease recurrence, even adrenocortical crisis. Academician Shen Ziyin has a wealth of clinical experience in both the withdrawal and reduction of ACH and the keeping of therapeutical effectiveness to form his unique remedy in the application of drugs. Shen's rich experience is described as follows.
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小儿感染期血浆皮质醇值的变化
糖皮质激素具有抗炎、抗毒、抗过敏及抗休克的作用.因此,感染期糖皮质激素浓度可反映机体的抗病能力和应激功能.人体中糖皮质激素以皮质醇为主,测定血浆皮质醇可作为肾上腺皮质分泌功能变化的指标.本文目的是了解化脓性感染患儿手术前后,肾上腺皮质功能的变化规律及临床意义.
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小儿肾上腺皮质癌
婴幼儿肾上腺皮质功能性病变,表现为使皮质醇症时,多系肾上腺皮质癌.我院1960~1979年共收治4例,均经手术切除.近期2例随访已超过2年,情况良好;1例术后死亡;1例未随访.今简要报导及讨论如下.