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Expression and function of transcription factor RUNX2in synovial tissues of rheumatoid arthritis
Objective:This study aimed to explore the expression profile of transcription factor Runt-related transcription factor 2 (RUNX2)in the synovial tissues of rheumatoid arthritis (RA) and its effect on the apoptosis of RA fibroblast-like synovial cells (RA-FLS),and to screen new targets for the diagnosis,treatment and prognosis of RA.Methods:The expression and localization of mRNA and protein of RUNX2 in the synovial tissues were detected by real-time quantitative PCR (qPCR)and immunohistochemical staining,respectively.The effect of the expression of exogenous RUNX2 on the apoptosis process of RA-FLS cell line MH7A was investigated by flow cytometry,and the activation of NF-κB signaling pathway was detected by western blotting.Results:The expression of RUNX2 mRNA was significantly higher in the synovial tissues from RA patients,compared to that in the OA patients (P<0.05).RUNX2 protein was mainly localized in the nuclear of the RA synovial cells.Overexpression of exogenous RUNX2 could notably decrease the apoptosis of RA-FLS,which was substantially reversed by pretreatment with SN50,a specific inhibitor of NF-κB pathway.Compared with blank group and negative control group (pCMV6-AC-GFP-vector),the apoptotic rate of exogenous RUNX2 overexpressing (pCMV6-AC-GFP-RUNX2) MH7A cells was significantly decreased (P<0.05).NF-κB signaling pathway activity was significantly increased (P<0.05),and this effect could be effectively reversed by NF-κB signal pathway-specific inhibitor SN5.Conclusion:The high expression of UNX2 in RA synoviocytes could significantly inhibit the spontaneous apoptosis of cells,and it was related to the abnormal activation of NF-κB signaling pathway.In-depth studies of RUNX2/NF-κB signaling pathways will help to identify novel therapeutic targets for RA.
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类风湿性颞下颌关节炎1例
类风湿性颞下颌关节炎(temporomandibular joint involvement in rheumatoid arthritis)是一种以颞颌关节炎症为主要症状的全身系统性疾病.常常伴有全身游走性、多发性关节炎,尤其以四肢小关节常受累,晚期可发生关节强直.本病临床并不少见.类风湿关节炎(rheumatoid arthritis,RA)患者有2%~86%可累及颞颌关节[1],患者较少首诊于口腔科,而内科医师往往忽视其颞颌关节症状.我科曾收治1 例急性RA性颞颌关节炎,现报道如下:
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MRI在早期类风湿关节炎中的应用价值
类风湿关节炎(rheumatoid arthritis ,RA) 是一种侵犯全身多个关节,滑膜先受累的结缔组织病,病程呈慢性、进行性、侵袭性,如果不及时治疗,病情进展迅速,滑膜增生形成血管翳,逐渐破坏关节软骨和软骨下骨,终致关节强直、畸形和功能丧失,并且关节畸形是一种不可逆性的损害.
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单核细胞 CD36的荧光强度与类风湿关节炎患者颈部动脉斑块形成的关系
目的:探讨单核细胞 CD36的荧光强度与类风湿关节炎(rheumatoid arthritis,RA)颈部动脉斑块形成的关系。方法选取2014-2015年在新疆医科大学第一附属医院就诊的200例 RA 患者,根据颈动脉彩色超声检查结果将 RA 患者分为动脉硬化斑块组和无动脉硬化斑块组。采用 ROC 曲线评估单核细胞 CD36的荧光强度对 RA 患者颈部动脉斑块形成的诊断价值。比较两组患者的单核细胞 CD36的荧光强度,并对两组患者相关实验室指标进行 Logistic 回归分析。结果两组患者超敏 C 反应蛋白(hypersensitive C-reactive protein,Hs-CRP)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、甘油三酯(Triglyceride,TG)以及单核细胞 CD36的荧光强度差异均有统计学意义(P <0.05)。Logistic 回归分析结果显示 Hs-CRP、LDL-C、TG 及单核细胞 CD36的荧光强度与 RA 患者颈部动脉斑块形成呈负相关(OR =1.921,P <0.01,95% CI :1.231~2.295)。单核细胞CD36的荧光强度每下降1个单位,RA 患者颈部动脉斑块形成的风险增加1.9倍。ROC 曲线下面积为0.906,敏感度为84.8%,特异度为81.5%,佳诊断点的 CD36荧光强度为0.61。结论单核细胞 CD36荧光强度与 RA 患者颈部动脉斑块形成密切相关,单核细胞 CD36荧光强度可提示 RA 患者颈动脉斑块形成的风险。
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膝关节类风湿关节炎的关节镜诊治
类风湿关节炎(Rheumatoid Arthritis RA)是一种以关节病变为主的全身性结缔组织病,其发病率及致残率都很高。目前国内外普遍应用的诊断标准,用于典型病例较易,但对部分症状隐匿的早期病人则很难以此完全确定,因而错过了早期诊治的机会,……
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59例幼年型类风湿关节炎患者家属遵医行为调查与分析
幼年型类风湿关节(Juvenile rheumatoid arthritis,JRA)是幼年时期发生的以慢性关节滑膜炎为主要特征的全身性自身免疫性疾病,多发生于16岁以下的儿童,以原因不明的慢性滑膜炎为主要特征[1-3].JRA的临床表现主要以关节炎症及关节功能受损为主,伴发发热、皮疹、肝脾肿大、等症状,常急性发作与缓解交替出现、病程迁延数年[4-5].遵医行为是指患者及家属在求医后其服药、饮食控制或改变生活方式等与临床医嘱相符合的程度[9].
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中西医结合治疗类风湿性关节炎疗效观察
2007年5月~2010年4月,我们用西药结合中药汽浴治疗类风湿性关节炎(RA)效果显著,报告如下.1 临床资料共112例,均为2007年5月~2010年4月本院住院患者.男14例,女98例;年龄20~60岁,平均(45±10)岁;病程(23.17±14.96)个月.随机分为治疗组56例和对照组56例,两组性别、年龄、病程均无显著性差异(P>0.05),具有可比性.
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五藤汤治疗类风湿性关节炎疗效观察
类风湿性关节炎是一种慢性全身性变态反应性疾病,以青壮年发病率为高,常为对称性,多侵犯指、腕、肘、膝、骶、髋、脊柱等关节,以双手小关节为常见,初期可有肿、胀、热、痛,晚期多发生梭状畸形强直、功能障碍.笔者以五藤汤治疗类风湿性关节炎32例,疗效较好,现介绍如下.