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三阴性乳腺癌的临床治疗现状
三阴性乳腺癌(triple negative breast cancer,TNBC)指的是肿瘤组织中雌激素受体(estrogenreceptor,ER)、孕激素受体(progesterone receptor,PR)、人类表皮生长因子受体2(human epidermalgrowth factor receptor-2,Her-2)均为阴性表达的一种高危乳腺癌,一直以来缺乏有效的治疗方法[1].该病是近两年来国际上总结分类的乳腺癌的一种特殊亚型,多发生于绝经前的年轻女性,约占乳腺癌的10%-17%[3,4],在非洲裔美国妇女中发病率尤高,且预后较差[5].
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艾滋病相关性卡波西肉瘤新进展
卡波西肉瘤(Kaposi’ssarcoma,KS)又称多发性特发性出血性肉瘤,是一种多中心起源的由血管和梭形细胞混合组成的恶性肿瘤.目前,人类免疫缺陷病毒(Human Immunodeficiency Virus,HIV)感染导致的严重免疫功能缺陷而引起各种机会性感染和(或)恶性肿瘤中,KS是常见的艾滋病(acquired immunodeficiency syndrome,AIDS)相关肿瘤[1].
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新生儿人巨细胞病毒感染与血清锌铜相关性的初步探讨
人巨细胞病毒(human cytomegalovirus,HCMV),是广泛危害人体健康的病毒之一,人群中血清IgG阳性波动率50%~100%之间[1],可引起先天性及围生期感染,新生儿的先天性HCMV感染的发病率为0.15%~2.0%[2],可表现为多器官受损,消化系统受累常见,其次为神经系统、泌尿系统、血液系统、呼吸系统等.本研究的目的是探讨新生儿巨细胞病毒感染与血清中锌、铜含量的相关性,为临床提供一项新的辅助诊治依据.
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槲皮素抑制离体人微血管内皮细胞增生
AIM: To investigate the role of quercetin (Que) in the proliferation of cultured human skin microvascular endothelial cells (MVEC). METHODS: Cell count and [methyl-3H]thymidine ([3H]TdR) uptake assay were used to measure the effect of Que in the proliferation of cultured MVEC. Cytotoxicity of Que on MVEC was also evaluated by 51Cr release assay. RESULTS: When MVEC were treated with Que, the proliferation was significantly inhibited in a time-course and dose-dependent manner. Que 5 μmol/L did not inhibit the proliferation of MVEC. When the concentration of Que increased to 20, 40, 80, and 160 μmol/L, the cell numbers per well were decreased and the inhibition rate was 12.2 %, 23.5 %, 35.3 %, and 54.1% respectively with IC50 of 138 μmol/L. The inhibitory rate of [3H]-TdR uptake was 18.7 %, 34.4 %, 48.9 %, and 62.5 % respectively (ICs0=87.5 μmol/L). 51Cr release assay showed that Que 160 μmol/L incubated with MVEC from 1 to 16 h had no clear cytotoxicity compared with control group. CONCLUSION: Que greatly inhibited the proliferation of cultured human MVEC in vitro. This effect may not be related to the cytotoxicity of Que on MVEC.