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巨细胞病毒感染后肝损害合并硬化性胆管炎1例
巨细胞病毒感染是由人巨细胞病毒( human cytomegalovirus,HC-MV)所引起.大多数人感染后没有什么症状,但是在免疫能力低下如胎儿和新生儿、先天性免疫缺陷病、器官移植和艾滋病患者则可发生危及生命的病变.巨细胞病毒感染后肝损害,合并硬化性胆管炎的情况较为少见,现报告如下.
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三阴型乳腺癌的研究进展
三阴型乳腺癌(triple negative breast cancer,TNBC)指的是雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和人类表皮生长因子受体-2 human epidermal growth factor receptor-2,Her-2)均为阴性表达的乳腺癌.TNBC的生物学特征不同于其他类型的乳腺癌,临床行为更具有侵袭性.
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摄取食物成分对血尿酸水平的影响
当降低血尿酸药物别嘌呤醇研发成功并普遍应用之后,高尿酸血症可简单地得到控制,虽然食物疗法在预防和控制高尿酸血症中发挥着非常重要的作用,却仍不能被较好地认知和掌握.严格地限制嘌呤摄入可以有效地降低每天尿中的尿酸排泄约200~400 mg(1.18~2.36 mm01),也可以使血尿酸降低59~mol/L(1 mg/dl).
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人乳头状瘤病毒感染与子宫颈癌
子宫颈癌是一种感染性疾病,主要由高危型人乳头状瘤病毒(human papillomavirus,HPV)感染所致.近年来,临床医生在宫颈癌和癌前病变的诊治与预防实践中对有关HPV的研究予以了关注,本文就一些热点问题予以简述.
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人乳头状瘤病毒感染与乳腺癌发生的关系
人乳头状瘤病毒(Human Papillomavirus,HPV)感染与宫颈癌发生和发展相关的研究源于30多年前,今天,科学界已经发现和证实了HPV感染是99%以上的宫颈癌病原体[1].HPV通过破坏宿主细胞蛋白质调控及引起染色体组不稳定,引发细胞基因突变,随着时间的推移累积进而发展成为癌症,对这个过程的认识和研究奠定了我们理解其他许多人类肿瘤发展的理论基础[2].
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人禽流感诊疗方案(试行)
人禽流行性感冒(以下称人禽流感)是由禽甲型流感病毒某些亚型的毒株引起的急性呼吸道传染病.1997年5月,我国香港特别行政区1例3岁儿童死于不明原因的多脏器功能衰竭,同年8月经美国疾病预防和控制中心以及世界卫生组织(WHO)荷兰鹿特丹国家流感中心鉴定为禽甲型流感病毒H5N1引起的人类流感,这是世界上首次证实禽甲型流感病毒H5N1感染人类.之后相继有H9N2、H7N7亚型感染人类和H5N1再次感染人类的报道.
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还科学以本来面目--对"克隆人事件"的冷静思考
近日来,有关"克隆人"的炒作在国际和国内掀起又一个高潮,公众们感到一头雾水.这到底是怎么回事?从某一方面说,这绝不是一种正常现象,因为它悖离了科学的本来面目.
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人乳头瘤病毒16型感染与机体免疫
宫颈癌是第一个被世界卫生组织认为100%与感染有关的癌症,人乳头瘤病毒16型(human papillomaviruses type 16,HPV16)是与宫颈癌相关的常见的HPV型别.据国际癌症研究中心(IARC)统计,宫颈癌标本中,HPV16型感染占51.0%.
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血清CA15-3、CA125、CEA联合检测乳腺癌65例
乳腺癌是女性常见恶性肿瘤之一,全世界的患病率成明显上升趋势,严重威胁妇女的身心健康,早期诊断,早期治疗是预防乳腺癌的有效的手段[1].研究选择敏感性和特异性相对较高的CA15-3、CE125和CEA进行联合检测,并选用人绒毛膜促性腺激素(human chorionic gonadotropin,hcG)作为对照,探讨其对乳腺癌早期诊断和鉴别的价值.
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人类免疫缺陷病毒检验
人类免疫缺陷病毒(human immunodeficiency vi-rus,HIY)又称艾滋病毒,是获得性免疫缺陷综合征即艾滋病(acpuired immunodeficiency syndrome,AIDS)的病原体,属逆转录病毒科(retroviridae)的慢病毒(lentivinrs)亚科,形态为典型的D病毒,主要通过性传播途径、血液传播途径和母婴传播途径传播.
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第27届欧洲人类生殖与胚胎学会会议多囊卵巢综合征专题概览
第27届欧洲人类生殖与胚胎学会(European Society of Human Reproduction and Embryology,ESHRE)年会于2011年7月3-6日在瑞典首都斯德哥尔摩召开.来自世界各地的研究者汇聚一堂,就生殖医学多个重点、热点问题进行了充分的讨论和学习.整个会场充满了浓郁的学术气氛.据会议工作人员统计,参会人员达9000余人,共接受摘要907份,其中与多囊卵巢综合征(polycystic ovary syndrome,PCOS)有关的论文摘粗略估计有60份以上,会议还就此专题在7月5日下午文举行了专场讨论.现对此次会议有关PCOS专题的内容介绍如下.
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艾滋病初筛实验室生物安全
获得性免疫缺陷综合征(acquired immunodefi-ciency syndrome AIDS,艾滋病)是由人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染引起的一种严重威胁人类健康的性传播疾病,被西方人称为"20世纪的新瘟疫".
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艾滋病流行的社会行为因素及行为干预措施
1 前言艾滋病亦称获得性免疫缺陷综合症(Acquired Immune Deficiency Syndrome,AIDS),是由艾滋病病毒(Human Immunodeficiency Virus,HIV)感染引起的以T细胞免疫功能缺陷为主的一种混合免疫缺陷病征.
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苯系物与噪声联合作用对人听力的影响
为探讨苯系物与噪声联合作用对听力的影响,我们对接触苯系物、噪声以及同时接触苯系物和噪声的作业工人进行了听力检测,报告如下.
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扁平苔藓皮损中朗格汉斯细胞分布及变化的研究
扁平苔藓(lichen planus,LP)是一种原因未明的慢性、亚急性、炎性皮肤病.皮损可发生于任何部位,四肢多于躯干,并常可累及黏膜.以往研究提示LP发病与发展可能与T淋巴细胞免疫功能相关[1],T细胞免疫功能的发挥有赖于抗原递呈细胞(antigen presenting cell,APC)递呈抗原信息的作用,而朗格汉斯细胞(Langerhans' cells,LC)是重要的APC.该研究采用免疫组织化学方法并应用连续切片对照观察了LC的标记抗原CD1a及人白细胞抗原DR(human leukocyte antibody DR,HLA-DR)在LP皮损中的复合表达,探讨 LC在LP发病中的作用.
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人粒细胞无形体病——一例报告并文献复习
人粒细胞无形体病(Human granulocytic anaplasmosis,HGA)为我国新发生的传染病,该病以发热,白细胞、血小板减少和多脏器功能损害为主要临床表现,并可有凝血异常、异常淋巴细胞增多等多项血液系统异常表现,易与血液系统疾病混淆,重症患者可因多脏器功能衰竭死亡.
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Objective:To determine the clinical serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers.
Methods:The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic (ROC) curves were plotted.
Results:Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined:in esophageal cancer, sensitivity=28%, negative predictive value (NPV)=61.72%, and AUC=0.742 (SE=0.05), with a significance level of P<0.0001;in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 (SE=0.05), with a significance level of P<0.0001;in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 (SE=0.04), with a significance level of P<0.0001. The sensitivity of CA19-9 was also evaluated:in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 (SE=0.05), with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 (SE=0.05), with a significance level of P<0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.580 (SE=0.05), with a significance level of P=0.1670. The following were the sensitivities of CEA/CA19-9 combined:in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 (95%CI:0.0159-0.322);gastric cancer, sensitivity=58%, NPV=70.42%, SE=0.072 (95%CI:-0.0866-0.198);and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 (95%CI:0.137-0.415).
Conclusion:CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer. -
HPV16 E6/E7 Negatively Affect Radiosensitivity of Lung Cancer Cells
Objective Lung cancer cells associated with radioresistance are likely to give rise to local recurrence and distant metastatic relapse,but little is known about its underlying mechanisms.In the present paper,the effects of the HPV16 E6 and HPV16 E7 oncoprotein on the radiosensitivity of lung cancer cell lines were investigated.Methods The HPV16 E6 or HPV16 E7 oncoprotein was expressed by a transient transfection with pcDNA3-HPV16 E6 or pcDNA3-HPV16 E7 expression vector.Human lung cancer H2179 cells and mouse lung cancer Lewis cells were exposed to a γ-ray radiation source,cellular survival was evaluated by using a colony formation assay.The expression of HPV16 oncoproteins E6/E7,extracellular signal-regulated kinases 1/2(ERK1/2) and AKT signaling was determined by Western blot assay.VEGF secretion was determined by ELISA.Results Both HPV16 oncoproteins E6 and E7 significantly decreased radiosensitivity of H2179 cells,associated with a promotion of the ERK1/2 and AKT phosphorylation.A decrease of reactive oxygen species(ROS) and an increase of VEGF levels were observed in the cells expressing the HPV16 oncoproteins E6 and E7.Furthermore,a similar reduction of radiosensitivity mediated by the HPV16 oncoproteins E6 and E7 was also observed in a mouse lung cancer Lewis cells.Conclusion The findings indicate that the HPV16 oncoproteins E6 and E7 negatively affects susceptibility of lung cancer cells to radiotherapy via regulation of the ERK1/2 and Akt signaling pathway and VEGF expression.
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重组人血管内皮抑素注射液联合化疗药物治疗晚期癌症的疗效及护理
重组人血管内皮抑素注射液是我国学者自主创新研发的新型人血管内皮抑素,适用于一切需要血液供应才能生长的实体瘤,如胃癌、肝癌、肠癌和乳腺癌等,作用机制在于有效抑制血管内皮细胞的迁移、阻断血管生长、中断肿瘤细胞营养和氧气的供应,终使肿瘤细胞处于休眠状态,达到饿死肿瘤细胞的目的[1].重组人血管内皮抑素注射液2006年已被非小细胞肺癌(NSCLC)临床实践指南(中国版)推荐为一线治疗药物.
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陕西省城乡中学生艾滋病知识、态度、行为的比较性研究
艾滋病(acquired lmmunodeficiency syndrome,AIDS)是由人类免疫缺陷病毒(human immunodeficiency virus, HIV)引起的病死率极高的恶性传染病,是人类前所未有的具有毁灭性的疾病.