Effects of Electro-acupuncture Preconditioning on Focal Cerebral Blood Flow in Artery and Vein of Rats with Middle Cerebral Artery Occlusion

Dl-3n-butylphthalide can effectively treat cerebral ischemia; however, the mechanisms underlying the effects of dl-3n-butylphthalide on microcirculation disorders fol owing diffuse brain injury remain unclear. In this study, models of diffuse brain injury were established in Sprague-Dawley rats with the vertical impact method. Dl-3n-butylphthalide at 80 and 160 mg/kg was given via intraperitoneal injection immediately after diffuse brain injury. Ultrastructural changes in the cerebral cortex were observed using electron microscopy. Cerebral blood flow was measured by laser Doppler flowmetry, vascular density was marked by tannic acid-ferric chloride staining, vascular permeability was es-timated by the Evans blue method, brain water content was measured using the dry-wet method, and rat behavior was measured by motor function and sensory function tests. At 6, 24, 48, and 72 hours after administration of dl-3n-butylphthalide, reduced cerebral ultrastructure damage, in-creased vascular density and cerebral blood flow, and improved motor and sensory functions were observed. Our findings demonstrate that dl-3n-butylphthalide may have protective effects against diffuse brain injury by ameliorating microcirculation disorder and reducing blood-brain barrier dam-age and cerebral edema.

大鼠上矢状窦闭塞后磁共振影像及病理研究

颅内静脉窦血栓为脑血管病的特殊类型,呈缓慢发病,临床表现不具特征性,极易延误诊断和治疗,病死率达5.5%～30.0%[1].为了提高临床医师对颅内静脉窦和静脉闭塞性疾病的认识水平,笔者以上矢状窦为例,设计了大鼠脑静脉窦闭塞动物模型,以观察颅内静脉窦闭塞后局部脑血流量(regional cerebral blood flow,rCBF)与MRI脑组织形态学改变间的关系,以及相关的病理学表现,确定颅内静脉高压后脑组织的特征性损害变化过程.

脑血流速度和血管搏动指数与年龄的关系

为探讨脑血流速度和血管搏动指数(PI)与年龄的关系,我们采用经颅多普勒(Transcranial Doppler,TCD)超声技术,对年龄21～69岁的2 228名健康查体者进行了TCD检测并进行分析.

应用经颅多普勒检测颅内压增高对脑血管功能影响的评估作用

Background:Intracerebral pressure is closely related to cerebral blood flow,and hence we can evaluate intracerebral pressure indirectly through investigating early changes in cerebral blood flow.In this study,transcerebral Doppler(TCD) was used to evaluate 32 patients with cerebral hypertension in early and recovery phase to evaluate its impact on cerebrovascular function.

一种新的兔株网膜下腔出血后症状性脑血管痉挛模型的建立

Objective To establish an experimental model of symptomatic cerebral vasospasm(CVS) after subarachnoid hemorrhage( SAH) in rabbits. Method 2 weeks after the ligation of bilateral common carotid arteries, We induced CVS by injecting arterial blood twice via a cranial hole 2 mm× 2 mm and then neurological symptoms ,cerebral blood flow(rCBF) and food intake were evaluated. Results Food intake and rCBF decreased and neurological disorders were observed. Conclusion An experimental rabbit model of symptomatic CVS can be established by injecting blood via a cranial hole after bilateral common carotid arteries ligation. ``

经颅三维多普勒技术对脑震诊断、疗效及愈后的评估

Objective In order to offer a noninvasive and objective examination method for assessing the clinical diagnosis and eurative criterion of concussion patients, the patients color three - dimensional transcranial doppler( 3D - TCD) characteristic at deferent phases, parameter and clincal manifestation were studied Method Parameter of Median Cerebral Artery(MCA), Base Artery(BA), the average peak forwand velocity of cerebral blood flow, train figure were tested by 3D - TCD within 24 hours, 3 - 6 days and at the end of treatment, respectively. The results were compared with clinical diagnoses and curative criterion. Result Among 135 patients who had clinically diagnosed concussion, agreeable diagnoses 101 cases, basically agreeable diagnooses 12 cases, disagreeable diagnosis 22 cases(16. 2%) .At the end of treatment, according to clinical determination 96 cases(71.1%) were cured, 39 cases(28.9%) were improved. Wave train character, figure and diagnoses prameter of cerebral spasm caused by concussion were suggested Conclusion To be one of the diagnostic bases and curative criterion, 3D- TC D technology is performable. Meanwhile, it is a new testing objective technique for assessing curative and determining prognosis.

PET在抑郁症研究中的应用

抑郁症是一种慢性而易原发的疾病.流行病学资料显示,在全球疾病负担中,1990年抑郁症占第四位,2020年抑郁症将升至第二位.近年来,对于抑郁症的病理机制和治疗的研究显得日趋重要.从1985年至今[1],正电子发射断层扫描技术(Position Emission Tomography,PET)逐渐成为研究抑郁症的一种有效工具.通过对活体大脑的功能活动状态实时观测,客观地描绘出生理或病理情况下局部脑血流(regional cerebral blood flow,rCBF),局部脑葡萄糖代谢率(regional cerebral glucose metabolic rate,rCMRglu)以及神经受体的结合情况.研究范围涉及抑郁症的多个领域,诸如神经解剖、神经生化、药理学、治疗学等.现将近年来的相关文献综述如下.

脑梗死病人脑血流与记忆的相关研究

脑梗死是由于脑局部血液循环障碍所致的常见多发疾病，脑梗死可引起各种神经功能障碍，包括记忆障碍。本研究对30例脑梗死患者进行脑血流量和记忆功能测定，对二者间相互关系进行初步探讨。1 对象与方法1.1 研究对象 病人组：30 例住院的脑梗死患者，男性20例，女性10 例，年龄50～64岁，平均56.6±6.9岁。受教育年限3～12年，平均6.8±4.2年。诊断符合1986年全国第二届脑血管病会议标准，并经头颅CT 扫描证实，左半球梗死16例，右半球梗死14 例。