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控制糖尿病患者心血管风险行动的临床试验解读
ACCORD研究(evolution of the lipid trial protocol of the action to control cardiovascular risk in diabetes trial,ACCORD)~([1])的中文全称为"控制糖尿病患者心血管风险行动的临床试验".该研究始于2001年,由美国国立卫生研究院(NIH)资助.该研究旨在明确强化血糖控制、强化血压控制和联合调脂对高危糖尿病患者心血管事件的影响.
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特殊需要儿童言语嗓音康复课程标准及其实施方案
言语听觉康复课程标准是华东师范大学言语听觉科学教育部重点实验室的重点课题之一,是为了适应我国言语听觉康复科学发展的需要,满足特殊教育学校、聋校以及康复机构科学、有效、规范地开展言语康复工作,切实提高特殊需要儿童言语康复水平的需要而迫切研究的课题.
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三步图像重组法在心房颤动患者64层螺旋CT冠状动脉成像中的应用
近几年来,64层CT冠状动脉成像(CTCA)作为一种无创、有效、准确的检查手段,已广泛应用于对冠状动脉疾病进行筛查[1,2],由于其较高的时间分辨率和空间分辨率,在稳定的窦性心律及平均心率低于70次/min的情况下,可获得满意的图像质量.
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信息动态
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临床试验方案的设计要点
始撰写试验方案.
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临床试验过程的分类及分期
试验方案(Protocol)足整个试验的蕊图,它叙述试验的背景、理论基础和目的,试验设汁、方法和组织,包括统计学考虑、以及试验执行和完成的条件和要求.
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Cochrane系统评价的制作周期
ObjectiveTo calculate the typical time taken to complete protocols and reviews, to track how often reviews are updated and compare with Collaboration policies, to feed back any gaps in documentation of dates to individual Cochrane Collaborative Review Groups, and to suggest changes to presentation of reviews and to editorial processes.MethodsData were extracted either from The Cochrane Library or a specially constructed database to calculate the age of reviews and protocols, and the frequency of updating of reviews. Issue 1, 2003, with 1 596 reviews and 1 200 protocols, was used as the index issue.ResultsMedian number of issues between a protocol and its completed review being published on The Cochrane Library is 5 (1.25 years). 65% of protocols have appeared on The Cochrane Library for no longer than two years, but the number of protocols more than two years old is probably increasing. One-third of reviews have been substantively updated, but generally only once and often within several months of the first publication of the review. The number of out-of-date reviews is probably increasing. ConclusionsWhile the stage between publishing a protocol and the completed review is usually completed in no longer than two years, the number of out-of-date reviews and protocols requires continuing attention. How up-to-date a review is depends on when the evidence base was last searched and when additional relevant evidence has been integrated into the review. This needs to be reflected in the information provided to readers of Cochrane Reviews and some alternative ways of presenting the components of this information are given. More accurate and complete reporting will also allow the Collaboration to track progress against policy.
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NP方案治疗1例肺低分化癌伴肉瘤样改变病例报道
肺肉瘤样癌 (pulmonary sarcomatoid carcinoma,PSC)是一种少见的肺部肿瘤,恶性程度高,目前国内外对PSC化疗方案的选择及疗效的报道较少.本文报道1例有远处转移的肺低分化癌伴肉瘤样改变的病例经过2次NP方案(长春瑞滨+顺铂)治疗后取得部分缓解.