微创下经皮伤椎植骨联合脊柱外固定治疗青壮年胸腰椎骨折

外伤所致的青壮年新鲜胸腰椎骨折常用手术方法是开放复位内固定加植骨融合术,有些不需要椎管减压者可只行开放复位内固定不植骨.但此种手术创伤大,出血多,跨节段融合,脊柱活动度丢失较大,以后仍需二次手术取出内固定.我院2008年1月～2012年1月采用微创下经皮伤椎椎体植骨联合脊柱外固定治疗青壮年胸腰椎骨折患者32例,取得了较为满意的疗效,报道如下.

第一届国际儿童及青年心力衰竭学术会议概况

第一届国际儿童及青年心力衰竭学术会议由美国贝勒(Baylor)医学院儿科系和德克萨斯儿童医院心脏中心主办,于2003年12月3～6日在美国休斯顿召开.来自32个国家和地区500余人参加会议.这次会议邀请国际上从事心力衰竭及相关研究的专家作了41次专题演讲.会议期间还有特殊病例的介绍、论文口头交流及壁报交流.会议的主要内容有以下几方面.

Objective To evaluate the effectiveness of a community-based acquired immunologic deficiency syndrome (AIDS) educational intervention in young adults.Methods A quasi-experimental design was used. Two townships in Kunshan county, matched by socioeconomic characteristics, were randomly assigned to intervention or control group. Eight hundred young adults aged 18-30 were recruited from the two townships as study subjects. A 12-month comprehensive educational intervention on AIDS prevention was conducted in the intervention group through local family planning services.Results After intervention, subjects in intervention significantly improved their knowledge on AIDS and attitudes related to AIDS prevention. Reported rate of condom use during the last episode of sexual intercourse increased from 8.5% at baseline to 14.4% after intervention (χ2=4.66, P=0.0308). No obvious change was observed among subjects in control group.Conclusion This study demonstrated the feasibility of integration of AIDS educational intervention into the existing family planning services. Integration of AIDS programs into family planning program should be considered as a realistic approach for AIDS control in China.

老年人哮喘气道高反应性与肺功能相关性研究

Background: The diagnosis and treatment of cough variant asthma in young adults could be performed properly. Cough variant asthma of elders was often diagnosed as bronchia－ lung infection due to its untypical symptoms. Incorrect diagnosis delayed the condition and aggravated the patients' suffering. Cough variant asthma in elders should be cautioned in clinic. Evaluation of broncho－ hypereactivity(BHR) should be done when dubious condition encountered. Objective: To explore the relationship between BHR and pulmonary function, and the improvement of pulmonary function after treatment.

儿童期起病的生长激素缺乏患者在青少年时期的生长激素水平——对胰岛素耐量试验的重新评价

一些研究发现许多儿童期起病的生长激素缺乏(COGHD)患儿在青春早期或晚期复查时,已不再缺乏生长激素.

糖尿病病程,血糖控制以及传统心血管危险因素对青少年2型糖尿病患者动脉粥样硬化早期变化的影响

心血管疾病是成年2型糖尿病患者的主要死因.近有文献报道,接近70%的2型糖尿病成人将死于心血管事件.虽然近二十年来,2型糖尿病在青少年中的发病率明显增高,但对该群体中心血管疾病的早期发展和动脉硬化的进程所知甚少.

青年食管癌和胃癌

食管癌(esophageal carcinoma,EC)是世界上常见的六大恶性肿瘤之一,预后极差,中晚期病人5年生存率仅为10%左右[1].胃癌(gastric carcinoma,GC)的发生率在近的30年中虽有所下降,然而它仍名列所有恶性肿瘤的前茅.食管癌和胃癌的发病多在50岁以后,以中老年人常见.但是,近年发现青年(≤40岁)食管癌和胃癌并不罕见,且发病有增高趋势.

Bradykinin (BK) is a calcium/calmodulin dependent protein kinase Ⅱ (CaMKⅡ) specific activator, and Cyclosporin A (CSA) is reported to suppress protein phosphotase (PP)-2B activity. In vitro studies have shown that CaMKⅡ and PP-2B play an important role in Alzheimer-like phosphorylation of microtube-associated protein tau. To reconstitute an animal model based on the imbalance of protein kinase (s) and protein phosphatase (s) seen in Alzheimer brain, we injected BK and/or CSA into rat hippocampus. The results from behavioral study showed that an obvious disturbance in learning and memory was seen with BK or BK plus CSA injected rats. Moreover, the behavior abnormality appeared earlier in aged rats than young adults of the same kind after the injection. On the other hand, no obvious dysfunction in living and behavior was observed with CSA alone injected rats. The results obtained by immunohistochemical assay indicated that the staining for M4\, 12E8\, PHF-1 and CaMKⅡ was stronger, and for Tau-1 was weaker in BK injected rats compared with Control group. It was also found that the binding of M4 and PHF-1 but not 12E8 to tau was significantly increased in CSA injected rats. As the same as BK injection, binding of Tau-1 to tau was decreased after CSA injection. The immunostaining for 12E8\,PHF-1 and CaMKⅡ was increased, whereas for Tau-1\, M4\, and GSK-3 was decreased after combination injection of BK and CSA. In addition, the staining of PP-2B decreased in all the three models. To our knowledge, this is the first data shown in vivo that the activation of CaMKⅡ induces both Alzheimer-like tau phosphorylation and behavioral disturbance.