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Oncogenic IGFBP-2 Contributes to Tumor Initiation and Development
关键词: Development -
Integrative genomic Analysis of Breast Cancer Metastasis
Discovering metastasis genes that are clinically relevant and functionally important are critical for the development of novel therapeutics for high-risk breast cancer patients.
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The New Lung Cancer Staging System
The International Association for the Study of Lung Cancer (IASLC) has conducted an extensive initiative to inform the revision of the lung cancer staging system. This involved development of an international database along with extensive analysis of a large population of patients and their prognoses. This article reviews the recommendations of the IASLC International Staging Committee for the definitions for the TNM descriptors and the stage grouping in the new non-small cell lung cancer staging system.
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Dentin matrix protein 1 (DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment. Primarily, DMP1 is considered as an extracellular matrix protein that promotes hydroxyapatite formation and activates intracellular signaling pathway via interacting with avb3 integrin. Recent in vitro studies suggested that DMP1 might also act as a transcription factor. In this study, we examined whether full-length DMP1 could function as a transcription factor in the nucleus and regulate odontogenesis in vivo. We first demonstrated that a patient with the DMP1 M1V mutation, which presumably causes a loss of the secretory DMP1 but does not affect the nuclear translocation of DMP1, shows a typical rachitic tooth defect. Furthermore, we generated transgenic mice expressing NLSDMP1, in which the endoplasmic reticulum (ER) entry signal sequence of DMP1 was replaced by a nuclear localization signal (NLS) sequence, under the control of a 3.6 kb rat type I collagen promoter plus a 1.6 kb intron 1. We then crossbred the NLSDMP1 transgenic mice with Dmp1 null mice to express the NLSDMP1 in Dmp1-deficient genetic background. Although immunohistochemistry demonstrated that NLSDMP1 was localized in the nuclei of the preodontoblasts and odontoblasts, the histological, morphological and biochemical analyses showed that it failed to rescue the dental and periodontal defects as well as the delayed tooth eruption in Dmp1 null mice. These data suggest that the full-length DMP1 plays no apparent role in the nucleus during odontogenesis.
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C-反应蛋白:炎性标记物抑或是动脉粥样硬化血栓形成的参与者
C-reactive protein (CRP) was traditionally considered a biomarker of inflammation,however,recent studies have proved that CRP exerts prothrombotic effects on vascular cells and plays a critical role in atherothrombosis.CRP increases the risk of ischemic vascular events,for example,myocardial infarction.CRP has been detected in atherosclerotic lesions in human coronary arteries [1-5].Although CRP has been argued to be involved in the development of atherosclerotic plaque size [6-8],it is surely correlated with activating the blood coagulation system and increasing the risk of thrombosis.The present review focuses on the pivotal role of CRP in trigger of atherosclerosis,stimulation of prothrombetic factor and activation of platelets as well as subsequent development of atherothrombosis.A better understanding of each step involved in this complex process might lead to a new therapeutic strategy to manage patients with CRP-linked atherothrombosis.
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干细胞用于创伤修复的新进展
皮肤组织的创伤修复是整形和烧伤外科中常见的问题,它需要在细胞迁移、细胞增殖和细胞外基质沉积的共同作用下,通过三个相互重叠但又彼此不同的阶段:炎症期、增殖期及成熟期来完成[1]。对于较浅的烧伤创面或小面积的皮肤全层缺损,可以通过残存皮肤附件的干细胞再生或临近皮肤的上皮细胞迁移而愈合。对于较深的创面,如:Ⅲ度烧伤创面或大面积的皮肤全层缺损,需要采用自体皮肤或人工组织工程化皮肤进行修复。临床常用的修复方法存在着许多缺点,如:造成供区的损伤,大面积烧伤患者缺乏足够的自体皮肤,而异体皮肤移植存在免疫排斥反应等。因此,促进皮肤创伤修复已成为组织修复领域亟待解决的难题之一,研究皮肤创伤愈合修复具有重要的理论和实际意义。
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预防正畸矫治过程中牙釉质脱矿的研究进展
釉质脱矿已经成为固定正畸治疗过程中为严重的并发症之一,研究显示固定矫治过程中牙面脱矿的发病率接近60%,且以青少年患者尤为多见[1].因此,广大学者和正畸临床医生一直努力寻找一种可靠、有效的预防措施.本文就目前常用的预防措施综述如下.
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整形美容患者心理研究进展
随着社会的进步,人们经济水平及爱美意识的提高,人们对美的追求也越来越高,希望通过手术或非手术方式使自己的容貌、体型变得更美、更迷人.
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罂粟碱在整形外科中的应用进展
罂粟碱的通用名为盐酸罂粟碱(papaveringe hy-drochlo-ride),是一种鸦片类生物碱,化学名称为1-[(3,4-二甲氧基苯基)甲基]-6,7-二甲氧基异喹啉盐酸盐,为血管扩张药.
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皮肤衰老机理及延缓衰老化妆品的研究进展
衰老(Aging)又称老化,是任何生物生命活动进程中的必经阶段,是生物体发育成熟后,随年龄增长而发生的渐进的、受遗传因素影响的、全身复杂的形态结构与生理功能不可逆的衰退过程.皮肤是人体大的器官,担负着保护、感觉、调节体温、分泌、排泄和免疫等诸多方面的作用,随着年龄的增长,皮肤也会像人体的其他器官一样逐渐老化,功能减弱、丧失,产生各种病变等.本文就皮肤衰老机理及延缓衰老化妆品的研究进展综述如下.
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神经调节蛋白1在神经发育中的研究进展
神经调节蛋白1(neuregulin 1,NRG1)是一类含有表皮生长因子样结构域的营养因子.NRG1与其受体ErbB构成的NRG1-ErbB信号通路在神经发育中发挥着重要作用,与精神分裂症等神经发育异常所导致的疾病密切相关.更好的理解NRG1-ErbB在神经发育中的机制有助于发展更有效的针对神经发育疾病的治疗措施,现就近年来NRG1在神经发育中的研究进展作一综述.
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磁敏感成像在中枢神经系统疾病的研究进展
磁敏感加权成像(susceptibility weighted imaging,SWI)是一种利用不同组织间的磁敏感性差异产生影像对比的磁共振成像方法,目前已被广泛应用于中枢神经系统.本文就SWI在脑外伤、出血、梗死、脑血管畸形、脑肿瘤、铁质沉积及某些神经变性疾病中的应用作一综述.
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国人腰椎管径值测量的研究进展
腰椎椎管是由腰椎椎体后缘、椎间盘、椎弓根、椎板以及黄韧带等围成.向上与胸椎椎管相通,两侧与腰椎神经根管相连续.一般将腰椎椎管划分为中央椎管、侧隐窝和神经管3部分.椎管径值的正常大小很重要,椎管口径的大小直接影响脊髓及神经根的功能,腰椎管径值的减小会导致个体的后背疼痛.在年龄、体重、体型、种族差异以及腰椎管大小之间存在一定的联系.土耳其的Tacar等[1]认为许多环境因素包括胎盘重量、低出生体重和低社会经济地位可能影响椎管的发育.目前对于腰椎管径值的大小以及对腰椎管狭窄的判定还没有统一的数据可询,结论亦不尽一致.
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我国民族医药教育发展概况
"百年大计,教育为本",民族的富强、祖国的繁荣昌盛都离不开教育.民族医药教育不仅是民族医药事业的重要组成部分,也是我国教育事业的重要组成部分.这就要求我们从实际出发,认真思考我国现有民族医药的教育体系,如办学主体、教育模式、教育层次、教育规模等等.现对我国民族医药教育发展状况综述如下.
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早产儿出生早期呼吸治疗与肺脑发育及损害的关系研究
影响新生儿远期预后的3大高危因素分别为支气管肺发育不良(BPD)、B超提示的脑损伤和重度早产儿视网膜病(ROP)[1].
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Heart rate variaty (HRV) of 85 cases with AMI was observed in the early phase after onset and rehabilitation phase at first month and sixth month, and was contrasted with six time threshold indices of 111 cases with coronary heart disease and that of 35 normal control. We found the HRV of AMI was apperantly lower in the acute phase than that of coronary heart disease and normal controls. HRV recovered gradually with inclining to be stable after half a year, but it was still lower than that of controls. Low HRV in early phase of AMI suggested the poor prognosis.
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Development大脑体操,开发左右脑
关键词: Development 大脑 体操